Dovitinib
Da K-Rene.
Inibitore
- FLT3 (IC50 = 1 nM),
- c-KIT (IC50 = 2 nM),
- FGFR (IC50 = 8 nM),
- VEGFR1/2/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively),
- PDGFRβ (IC50 = 27 nM), and
- CSF-1R (IC50 = 36 nM)
Dovitinib uguale a sorafenib in terza linea http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70030-0/abstract
