Fattore NF-kB
Uno dei maggiori meccanismi con cui l'infiammazione aiuta il cancro a progredire passa per una proteina chiamata nuclear factor kappa beta (NF-kB).
Nuclear factor kappa beta è consoiderato A major mechanism through which inflamm ation fuels cancer involves the production and activity of a protein called nuclear factor kappa beta (NF-kB). Cancer promoting triggers of nuclear factor kappa beta include injury, other inflammatory offenders such as diet, acidity, carcinogens, bacteria, viruses, oxidation, stress, radiation, chemotherapy, environmental stimuli, and additional factors. Nuclear factor kappa beta is considered a master switch in cancer accounting for approximately 95% of all cancers. Research indicates that nuclear factor kappa beta decreases cancer cell death (apoptosis) and increases cancer cell growth, blood supply to tumors (angiogenesis), invasion, and metastasis (1-5). Nuclear factor kappa beta also fuels inflammation through COX-2 enzymes and cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8). Studies suggest that high levels of IL-6 are correlated with shorter survival in some people with cancer. Along with promoting cancer invasion, IL-6 stimulates vascular endothelial growth factor (VEGF) responsible for increased blood supply to tumors through angiogenesis2. Nuclear beta copy What is the relationship between inflammation and cancer survival? What are the potential benefits of low inflammation levels in the body? Published research studies demonstrate inflammatory levels correlate with cancer. Low inflammatory levels appear to indicate reduced cancer risk and improved cancer survival6. High inflammatory levels appear to indicate increased cancer risk and poorer prognosis. Inflammation also decreases quality of life, impairs immune functions, plays a central role in cancer cachexia7, and lowers toleration of some anticancer therapies8. Research indicates that measuring inflammation may predict survival time for many cancers9. Some cancer studies suggest that people with the lowest levels of inflammation were twice as likely to live through the next several years10-12.
